Quick summary: Dentabiome contains 5 clinically studied oral probiotic strains plus a prebiotic and zinc — each component selected for documented evidence of oral microbiome support, gum health improvement, plaque control, and breath freshness.
Lactobacillus reuteri (ATCC PTA 5289 + DSM 17938)
The most clinically studied oral probiotic strain for periodontal health. Produces reuterin — a naturally selective antimicrobial that inhibits Porphyromonas gingivalis and other periodontal pathogens. Multiple randomized controlled trials indexed at PubMed document significant reductions in gingival index, plaque index, and bleeding on probing after 4 weeks of supplementation in patients with gingivitis and periodontitis. Also modulates inflammatory cytokine production in gingival tissue.
Lactobacillus salivarius
A natural oral cavity inhabitant producing bacteriocins that inhibit S. mutans, P. gingivalis, and Prevotella intermedia. Research confirms its persistent oral colonization and its ability to significantly reduce pathogenic bacterial populations. Also documented to inhibit biofilm formation by multiple oral pathogens, supporting both gum health and cavity prevention.
Streptococcus salivarius K12
The world's most studied oral probiotic strain for breath freshness and upper respiratory health. Produces salivaricin A2 and salivaricin B — BLIS (Bacteriocin-Like Inhibitory Substances) proteins that specifically target VSC-producing bacteria and streptococcal pathogens. Clinical trials published in journals indexed at PubMed document significant, sustained reductions in volatile sulfur compound levels and patient-reported breath quality improvements. Also reduces upper respiratory tract infections by inhibiting Streptococcus pyogenes.
Streptococcus salivarius M18
The dental-specific companion strain to K12. Produces dextranase and urease enzymes that break down glucan matrix in pathogenic plaque, plus bacteriocins that specifically target S. mutans. Research documents reductions in plaque scores and improvements in gum health markers. Works synergistically with K12 — the combination addresses both the plaque formation and breath dimensions of oral dysbiosis simultaneously. The NCBI indexes multiple clinical studies on M18's dental benefits.
Lactobacillus acidophilus
A broadly beneficial probiotic with documented anti-inflammatory properties relevant to gingival tissue health. Helps maintain balanced oral pH conditions that favor beneficial bacteria over acid-tolerant pathogens. Produces lactic acid at concentrations that inhibit pathogens while supporting the slightly acidic (but not excessively acidic) conditions preferred by beneficial oral species. Also contributes to systemic immune modulation that supports the body's response to periodontal bacterial challenges.
Inulin (Prebiotic)
A natural plant-derived prebiotic fiber that serves as preferential fuel for Lactobacillus species in the formula. The combination of probiotic strains with their specific prebiotic substrate significantly improves colonization persistence and long-term efficacy — this is a well-established finding in probiotic research. Without adequate prebiotic support, probiotic strains may not establish lasting colonization. The prebiotic-probiotic (symbiotic) combination in Dentabiome is specifically designed for maximal oral cavity colonization duration.
Zinc Citrate
An essential trace mineral with well-documented antibacterial and anti-plaque properties. Zinc ions inhibit bacterial adhesion to tooth surfaces, reduce S. mutans metabolism, and support gingival tissue repair. Research at PubMed confirms zinc's synergistic action with oral probiotics — its direct antibacterial effects on planktonic pathogens complement the probiotics' competitive exclusion in the biofilm.